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Description
Polyclonal antibody to detect RBBP4 in human, mouse and rat samples. Retinoblastoma associated proteins 46 and 48 (RBAP46 and RBAP48? also known as RBBP7 and RBBP4) were first characterized in human cells as proteins that bind to the retinoblastoma (Rb) tumor suppressor protein. Since then, these proteins have been shown to be components of many protein complexes involved in chromatin regulation, including the chromatin assembly factor 1 (CAF 1) complex and type B histone acetyltransferase complex HAT1, both of which function in chromatin assembly during DNA replication. RBAP46 and RBAP48 are also found in the nucleosome remodeling factor complex NURF, the nucleosome remodeling and histone de acetylation complex NuRD, and the Sin3/HDAC hist