A multi-targeted kinase inhibitor; exhibits greater than 40% inhibition of 34 of 104 kinases in an enzymatic assay at a concentration of 100 nM; has activity at multiple oncogenic kinases (IC50 values less than 50 nM); highly cytotoxic against a cancer cell panel that includes chemotherapy-sensitive and -resistant cell lines (EC50s = 0.4-158 nM); inhibits the growth of HUVECs (EC50 = 34 nM)