The T cell immunoglobulin mucin (TIM) gene family was discovered by positional cloning as molecules related to higher risk of development of asthma and allergic disease in mice. The TIM family includes three members in human and eight in mouse. TIM-1, TIM-3, and TIM-4 are conserved between mouse and human. Mouse TIM5 to TIM8 are inferred from genomic sequences and have not been characterized yet. TIM1 and TIM2 are expressed in Th2 and TIM3 in Th1. The TIM protein family members are type I cell membrane glycoproteins and share common structural motifs. The amino–terminal possesses immunoglobulin variable (IgV) domain with 6 cysteines, a mucin-like domain, followed by the transmembrane domain and a cytoplasmic domain with tyrosine phosphorylation motif, except in the human and mouse TIM4.? TIM4 is expressed in antigen presenting cells and interacts with TIM1 expressed in CD4 T cells; the interaction TIM4-TIM1 induces hyperproliferation in T cell. TIM4 is expressed in human and mouse macrophages and binds to phosphatidylserine expressed in apoptotic cells; thus, TIM4 mediates clearance of apoptotic cells. Also, TIM4 mediates filovirus entry (as well as TIM1), the Ebola virus (EBOV), a member of the Filoviridae family, binds to the human and mouseTIM-4 IgV domain expressed in macrophages and? dendritic cells, which are early cellular targets during EBOV infection.
Size
25 μg
Concentration
n/a
Applications
BA
Other Names
T-cell immunoglobulin mucin receptor 4, T-cell membrane protein 4, T-Cell Immunoglobulin And Mucin Domain Containing 4, TIM-4, TIMD-4, TIMD4, SMUCKLER