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Description
TCCR Monoclonal Antibody (34N4G11). Upon antigen challenge, T-helper cells differentiate into two functional distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-gamma and lymphotoxin-beta that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned. It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1. TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-gamma and Th1-dependent antibody IgG2a. TCCR is predominately expressed in thymus, spl
Immunogen
n/a
Other Names
class I cytokine receptor, CRL1IL-27R, Cytokine receptor-like 1, IL27R, IL-27RA, IL-27R-alpha, interleukin 27 receptor, alpha, interleukin-27 receptor subunit alpha, TCCRIL-27 receptor subunit alpha, T-cell cytokine receptor type 1, Type I T-cell cytokine receptor, WSX-1, WSX1IL-27R subunit alpha, zcytor1