A high-affinity ligand for retinoid X receptors (RXRs)(EC50 = 28, 25, and 20 nM for RXRα, β, and γ, respectively); inhibits cell cycle progression, induces apoptosis, and blocks angiogenesis and metastasis; stimulates clearance of soluble Aβ, reduces plaque area, and reverses deficits related to Alzheimer's disease in mice