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Description
Rabbit Anti-Human TGFBR2 monoclonal antibody for FC, ICC, IF, WB. TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. Three members of the TGF beta family, TGF beta1, TGF beta2 and TGF beta3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGF betas mediate their activity by high affinity binding to the type II receptor (TGF beta RII) transmembrane protein with a cytoplasmic serine-threonine kinase domain. For signaling growth inhibition and early gene responses the type II receptor requires both its kinase activity and association with a TGF beta-binding protein, designated the type I receptor. Two independent groups have recently described the cloning and sequence analysis of genes encoding TGF beta type I receptor proteins designated ALK-5 (T betaR-1) and TSR-1, respectively. Mutations have been associated with Marfan syndrome, Loeys-Deitz Aotic Aneurysm syndrome, and the development of various tumors.