Recombinant Human Tumor necrosis factor receptor superfamily member 6 (FAS)
Description
Purity > 85% as determined by SDS-PAGE. MW: 40.6kDa. Full Length of Mature Protein: 26-335aa. N-terminal 10xHis-tagged. Homo sapiens (Human). Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).