Recombinant Human Tumor necrosis factor receptor superfamily member 6 protein (FAS) (Active)
Description
Purity > 95% as determined by SDS-PAGE and HPLC. MW: 17.6kDa. Partial: 17-173aa. tag-Free. Homo sapiens (Human). Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). {ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:7533181}.