Recombinant Human Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)
Description
Purity > 90% as determined by SDS-PAGE. MW: 61.2kDa. Full Length: 1-312aa. N-terminal GST-tagged. Homo sapiens (Human). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.