Recombinant Human Tumor necrosis factor (TNF), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 21.4kDa. Partial: 77-233. N-terminal 6xHis-tagged. Homo sapiens (Human). Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Cachectin; TNF-alphaTumor necrosis factor ligand superfamily member 2; TNF-a