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Description
MARVELD2 Polyclonal Antibody. Tight junctions form an important barrier of paracellular transport in epithelial cells. Sealing of two adjacent cells at bicellular tight junctions (bTJ), is well described. The main structural components of bicellular tight junctions are claudins and occludin, all tetra membrane-spanning proteins. Less is known about the structure of tricellular tight junctions (tTJ), a point where three adjacent cells are in contact with each other. Tricellulin/MARVELD-2 (MARVEL domain-containing protein 2) is the first protein identified that specifically concentrates in tricellular tight junctions. This protein has four membrane-spanning domains, similar to claudins. Tricellulin expression is high in epithelium-derived tis