Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B) (Active) protein
Description
BAFF, a member of the TNF family of ligands, is expressed in T cells, macrophages, monocytes and dendritic cells. BAFF is involved in stimulation of B and T cell function, and is an important survival and maturation factor for peripheral B cells. BAFF signals through three different TNF receptors TACI, BCMA and BAFF-R. The human BAFF gene codes for a 285 amino acid type II transmembrane protein containing a 46 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 218 amino acid extracellular domain. Alternative Names: THANK protein, TNFSF13B protein, TALL-1 protein, B cell Activating Factor belonging to the TNF family protein, zTNF4 protein, BLys protein