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Description
LIN28A Monoclonal Antibody (14E6-4E6), DyLight 650. LIN28A/B are expressed in various cancers and ES cells. LIN28 is a cytoplasmic protein, that acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. LIN28 is a negative regulator of microRNA (miRNA) biogenesis by specifically binding the precursor of let-7 (pre-let-7). Let-7 miRNAs have been implicated in repression of oncogenes such as ras and myc. LIN28 expression decreases during differentiation of ES cells or upon induction of neuronal differentiation by retinoic acid.
Immunogen
n/a
Other Names
Lin-28 homolog A (C. elegans), RNA-binding protein LIN-28, LIN28A, CSDD1, Zinc finger CCHC domain-containing protein 1, ZCCHC1