Recombinant Mouse Scavenger receptor cysteine-rich type 1 protein M130 (Cd163), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 32.2kDa. Partial: 86-365aa. N-terminal 6xHis-tagged. Mus musculus (Mouse). Involved in clearance and endocytosis of hoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hoglobin/haptoglobin and subsequent breakdown of he. Binds hoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.After shedding, the soluble form (sCD163) may play an anti-inflammatory role.