Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) (pSer2448)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
human
Isotype
n/a
Format
affinity purified
Size
100 μg
Concentration
n/a
Applications
Western Blotting (WB),Immunohistochemistry (IHC),Immunocytochemistry (ICC)
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Description
The mammalian target of rapamycin (mTOR, FRAP, RAFT) is a Ser/Thr protein kinase that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth. When sufficient nutrients are available, mTOR responds to a phosphatidic acid-mediated signal to transmit a positive signal to p70 S6 kinase and participate in the inactivation of the eIF4E inhibitor, 4E-BP1. These events result in the translation of specific mRNA subpopulations. mTOR is phosphorylated at Ser2448 via the PI3 kinase/Akt signaling pathway and autophosphorylated at Ser2481. mTOR plays a key role in cell growth and homeostasis and may be abnormally regulated in tumors. For these reasons, mTOR is currently under investigation as a potential target for anti-cancer therapy.Synonyms: MTOR, FLJ44809, FRAP, FRAP1, FRAP2, RAFT1, RAPT1
Immunogen
A phospho specific peptide corresponding to residues surrounding pSer2448 of human mTOR/FRAP