Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) protein
Description
Pregnancy-associated plasma protein A, pappalysin 1, also known as PAPPA, is a protein used in screening tests for Down syndrome. PAPPA is a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. Description: Human retroplacental blood. Alternative Names: PAPP A Protein, Pregnancy Associated Plasma Protein A Protein, PAPP-A Protein