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Description
Rabbit polyclonal to NIK.NF-kappa-beta-inducing kinase (NIK) is also known as Mitogen-activated protein kinase kinase kinase14 (MAP3K14), which belongs to the protein kinase superfamily, STE Ser/Thr protein kinase familyand MAP kinase kinase kinase subfamily. NIK contains 1 protein kinase domain. NIK can be activatedby lymphotoxin beta, which seems to be exclusively involved in the activation of NF-kappa-B and itstranscriptional activity. NIK promotes proteolytic processing of NFKB2/P100, which leads to activationof NF-kappa-B via the non-canonical pathway. NIK can function in a receptor-selective manner.
Immunogen
N-terminal region of human NIK
Other Names
NIK,Mitogenactivated protein kinase kinase kinase 14,NFkappabetainducing kinase,HsNIK,Serine,threonineprotein kinase NIK,MAP3K14