Recombinant Human Glucocorticoid receptor (NR3C1), partial
Description
Purity > 85% as determined by SDS-PAGE. MW: 47.8kDa. Partial: 521-777aa. N-terminal 6xHis-Trx-tagged. Homo sapiens (Human). Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Nuclear receptor subfamily 3 group C member 1; GRL