A potent inhibitor of Aurora kinases (IC50s = 15, 25 and 19 nM for Aurora A, B, and C, respectively); also inhibits FLT3 as well as the constitutively active FLT3-ITD form (IC50s = 1.2 and 4.9 nM, respectively); orally bioavailable, inhibiting the growth of SW620 colon carcinoma xenografts in mice
Size
5 mg
Concentration
n/a
Applications
n/a
Other Names
biochemical cancer kinase protein signal transduction receptor biochemistry intracellular signaling CCT 13769 CCT-13769 inhibitor inhibit inhibition Aurora A B C tyrosine FLT3 FLT3-ITD growth SW620 colon carcinoma xenografts mice body weight loss MYCN neuroblastoma cell N-myc expression proliferation D835Y mutation colorectal radiotherapy