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Description
DUSP6 Antibody is a Rabbit Polyclonal antibody against DUSP6. The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.
Immunogen
Recombinant protein of human DUSP6.
Other Names
dual specificity protein phosphatase 6; dual specificity protein phosphatase PYST1; DUS6; DUSP6; MAP kinase phosphatase 3; mitogen-activated protein kinase phosphatase 3; MKP-3; MKP3; PYST1; HH19