Immunohistochemistry: 1:300-1:3000, Western Blot: 1:300-1:3000
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Description
TRPV6 Polyclonal Antibody. Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. Interacts with TRPV5, heterotetramer. Expressed in duodenu
Immunogen
n/a
Other Names
Transient receptor potential cation channel subfamily V member 6, TrpV6, Epithelial calcium channel 2, ECaC2, Calcium transport protein 1, CaT1, Trpv6