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Description
The tight junction is identified as a belt-like region in which two lipid-apposing membranes lie close together (tight junction strands). Tight junction strands of the adjacent cells form tightly connected pairs. The proteins involved in the formation of tight junctions are divided into two categories: 1) integral membrane proteins, such as occludin, claudin and junctional adhesion molecule, JAM and 2) peripheral membrane proteins (cytoplasmic plaque proteins), MAGUK (membrane-associated guanylate kinase) homologue proteins, such as ZO1, 2, 3, cingulin, symplekin, 19B1, and AF6. In human, the claudin superfamily consists of at least 18 members, which are involved in paracellular transport as structural and functional components of tight junction. Claudins are directly associated with ZO1, 2 and 3 and indirectly with AF6 and cingulin. Description: Serum. Synonyms: Polyclonal Claudin 12 antibody, Anti-Claudin 12 antibody.
Immunogen
Claudin12 antibody was raised in rabbit using a synthetic peptide corresponding to part of the C terminal of Mouse Claudin12 (GMHTYSQPYSSRSRLSAI) as the immunogenSerum