Recombinant Human Long-chain-fatty-acid--CoA ligase 5 (ACSL5), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 76.4kDa. Cytoplasmic Domain: 33-683aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells