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Description
Function: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.Subunit: Heterodimer. Interacts with DSIPI, this interaction inhibits the binding of active AP1 to its target DNA. Interacts with MAFBSubcellular location: Nucleus. INDUCTION: C-fos expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury. SIMILARITY: Belongs to the bZIP family. Fos subfamily SIMILARITY: Contains 1 bZIP domain Also known as: Proto-oncogene protein cFOS.
Immunogen
A synthetic peptide from aa region 300-380 of human c Fos protein conjugated to an immunogenic carrier protein has been used as the antigen.