Alpha-2 macroglobulin is a tetrameric glycoprotein MW 725 kDa. Synthesized in the liver, it is a serine proteases inhibitor. It inhibits coagulation by inactivating thrombin and kallikrein, it inhibits fibrinolysis by inactivating plasmin and it is also involved in insulin transport. It is the principal defensin binding protein. It is raised in cirrhosis, pregnancy and diabetes. Description: Human plasma. Alternative Names: alpha Macroglobulin 2 protein, alpha Macroglobulin 2, CPAMD5 protein, alpha 2M protein, alpha 2 Macroglobulin, S863 7 protein, alpha Macroglobulin-2, alpha Macroglobulin-2 protein, FWP007 protein, alpha 2 M protein, A2M protein, DKFZp779B086 protein