Recombinant Candida albicans Hyphal wall protein 1 (HWP1), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 24.2kDa. Partial: 27-203aa. N-terminal 6xHis-tagged. Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast). Major hyphal cell wall protein which plays a role of adhesin and is required for mating, normal hyphal development, cell-to-cell adhesive functions necessary for biofilm integrity, attachment to host, and virulence. Promotes interactions with host and bacterial molecules, thus leading to effective colonization within polymicrobial communities. Plays a crucial role in gastrointestinal colonization, in mucosal symptomatic and asymptomatic infections, in vaginitis, as well as in lethal oroesophageal candidiasis, caused by the combined action of fungal virulence factors and host inflammatory responses when protective immunity is absent.