Recombinant Human RB1-inducible coiled-coil protein 1 (RB1CC1), partial
Description
Purity > 85% as determined by SDS-PAGE. MW: 47.7kDa. Partial: 1241-1594aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Homo sapiens (Human). Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway through induction of RB1 expression. Plays a crucial role in muscular differentiation. Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
FAK family kinase-interacting protein of 200 kDa (FIP200) (KIAA0203) (RBICC)