A selective L-type calcium channel blocker with long-acting antihypertensive activity; relaxes depolarization-induced contractions of rabbit aorta (EC50 = 1.4 nM) and reduces the rate of spontaneously beating guinea pig right atria (EC25 = 0.45 nM); attenuates β-amyloid oligomer toxicity in an in vitro model of Alzheimer's disease by suppressing calcium influx into the cytoplasm and Cav1.2 expression