MUSK, Recombinant, Human, GST-Tag (Muscle/Skeletal Receptor Tyrosine Protein Kinase)
Description
Purified (~70-90%). MUSK is a receptor tyrosine kinase necessary for neuromuscular junction formation. MUSK gene expression is highly regulated during neuromuscular junction and it is involved in intercellular communication present on the surface of cells that are activated by specific protein ligands. MUSK members play a key role in growth and differentiation of those cell types. Agrin signals through MUSK to cluster acetylcholine receptors on the postsynaptic membrane of the neuromuscular junction. DOK7, a MUSK-interacting cytoplasmic protein, is essential for MUSK activation in cultured myotubes. MUSK also plays a critical role in the development of normal blood vessels. Source: Recombinant protein corresponding to human MUSK, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~63kD Specific Activity: 6.7nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL)