Purity > 90% as determined by SDS-PAGE. MW: 39.6kDa. Full Length of Mature Protein: 2-113aa. N-terminal GST-tagged. Homo sapiens (Human). Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, ses to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
CKII beta-binding protein 1; CKBBP1RING finger protein 7Regulator of cullins 2Sensitive to apoptosis gene protein