Purity ≥99% (HPLC, TLC). Important, highly specific inhibitor of the kinase known variously as p38, p40, CSBP, or RK. This kinase is a homolog of MAP kinase. Gallagher, T.F., et al. 2,4,5-Triarylimidazole inhibitors of Il-1 biosynthesis. Bioorg. Med. Chem. Lett. 5: 1171-1176 (1995). Cuenda, A., et al. SB203580 is a specific inhibitor of MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364: 229-233 (1995). Hazzalin, C.A., et al. Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli. Oncogene 15: 2321-2331 (1997). Solubility: Soluble in DMSO at 100mg/ml; soluble in ethanol at 12.5mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Size
25mg
Concentration
n/a
Applications
n/a
Other Names
[4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole; SAPK2, p38 Inhibitor; Stress-activated Protein Kinase 2 Inhibitor