An Akt inhibitor that reduces the level of phosphorylated Akt (IC50 = ~0.8 μM); binds Akt and blocks its translocation to the cell membrane; reduces cell proliferation in cancer cell lines, induces apoptosis, and, at a dose of 10 mg/kg/day, decreases tumor growth in a mouse xenograft model; inhibits cell growth (IC50s = 2-5 μM) and induces apoptosis in NSCLC and HNSCC cell lines; increases cleavage of caspases 8, 9, and 3; reduces c-FLIP levels through ubiquitin/proteasome-mediated degradation; synergistically induces apoptosis in combination with TRAIL/APO-2L