Interferon-gamma (IFN-gamma, also known as Type II interferon or immune interferon) is a cytokine produced primarily by T-lymphocytes and natural killer cells. The protein shares no significant homology with IFN-beta or the various IFN-alpha family proteins. Mature IFN-gamma, exists as noncovalently-linked homodimers. Human IFN-gamma, is highly species specific and is biologically active only in human and primate cells.IFN-gamma, was originally characterized based on its antiviral activities. The protein also exerts antiproliferative, immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms. IFN-gamma, induces the production of cytokines, upregulates the expression of class I and II MHC antigens, Fc receptor and leukocyte adhesion molecules. It modulates macrophage effector functions, influences isotype switching and potentiates the secretion of immunoglobulins by B cells. IFN-gamma, also augments TH1 cell expansion and may be required for TH1 cell differentiation. Synonym: Interferon-gamma ( IFN-gamma, ), Rat. Formulation: Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4.