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Description
BMP-2 belongs to the TGF- superfamily of proteins. BMP-2 plays an important role in the development of bone and cartilage. It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine-cytokine receptor interaction. It is involved also in cardiac cell differentiation and epithelial to mesenchymal transition. Implantation of BMP-2 in a collagen sponge induces new bone formation and can be used for the treatment of bony defects, delayed union, and non-union.
Immunogen
This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) of BMP2.