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Description
BMP-7, or osteogenic protein 1 (OP-1), is one of at least 15 structurally and functionally related BMPs, all members of the transforming growth factor beta (TGF-beta) superfamily. BMPs regulate cartilage and bone formation, embryogenesis and morphogenesis of various tissues and organs, and the growth, differentiation, chemotaxis and apoptosis of various cell types. Biologically active BMP-7 is a disulfide-linked homodimer. Cellular responses to BMP-7 have been shown to be mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors.