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Description
Bone morphogenetic proteins (BMPs) were first identified as molecules that can induce ectopic bone and cartilage formation . BMPs belongs to the TGF-beta superfamily, playing many diverse functions during development . BMPs are synthesized as precursor proteins and then processed by cleavage to release the c-terminal mature BMP. BMPs initiate signaling by binding to a receptor complex containing type I and type II serine/threonine receptor kinases that then phosphorylate Smad (mainly Smad1, 5 and 8), resulting the translocation of Smad into the nucleus. BMP was also reported to activate MAPK pathways in some systems . BMP7, also known as osteogenic protein-1 (OP-1), is found to be upregulated in some cancer cells , and may play a role in cancer metastasis . Synonyms: BMP7,OP-1 ,