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Description
NOTCH3 Antibody is a Rabbit Polyclonal antibody against NOTCH3. NOTCH3 belongs to the NOTCH family. It functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. NOTCH3 affects the implementation of differentiation, proliferation and apoptotic programs. Defects in NOTCH3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). The antibody is specific to NOTCH3.
Immunogen
A synthetic peptide of human NOTCH3.
Other Names
ADASIL; CASIL; CADASIL; Neurogenic locus notch homolog protein 3; Notch 3; NOTCH3; Neurogenic locus notch homolog protein 3Notch 3; Notch 3 extracellular truncation; Notch 3 intracellular domain; Notch homolog 3 (Drosophila); HGNC:7883; Notch (Drosophila) homolog 3; Notch homolog 3