Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1)
Clone
C7
Host Species
Armenian Hamster
Reactive Species
mouse
Isotype
IgG
Format
fluorescein (FITC) conjugate
Size
50 μg
Concentration
n/a
Applications
Flow Cytometry (FACS),Immunofluorescence (IF)
Reviews / Ratings
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Description
NKG2D serves as a stimulatory immunoreceptor to activate NK cells via the non-covalently associated DAP10 or DAP12 adaptor. Several molecules have been identified as the ligands for NKG2D, including minor histocompatibility molecule, H60, UL16-binding protein-like transcript 1 (Mult1, and a family of retinoic acid early transcript 1 (Rae1) in mice, MHC class-I chain-related protein A (MICA), MICB, and UL16-binding proteins (ULBPs) in humans, present in both mice and humans. NKG2D ligands trigger cytokine (IFN-gama, GM-CSF, TNF-alpha, MIP1beta and others) and granzyme release from NK cells.