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Description
FLT3 (Tyr599) Polyclonal Antibody, Alexa Fluor? 555 Conjugated. ? Target Background: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or ST
Immunogen
KLH conjugated synthetic phosphopeptide derived from human FLT3 around the phosphorylation site of Tyr599