Calreticulin is involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity. It constitutes together with calnexin and ERp57 the `calreticulin/calnexin cycle' that is responsible for folding and quality control of newly synthesized glycoproteins. Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule. Recently, Calreticulin was shown to enhance the merger of macrophages and tumor cells, increasing phagocytosis. MW: ~55.0 kDa. Human calreticulin (aa 18-417) is fused at the C-terminus to a His-tag. Purity ≥90%
Size
50 μg
Concentration
n/a
Applications
RUO
Other Names
CRP55; Calregulin; Endoplasmic Reticulum Resident Protein 60; ERp60; grp60