An MMP inhibitor (Kis = 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively); reduces 5-aza-2'-deoxycytidine-induced increases in MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, and MMP-14 expression in as well as cell invasion by AsPC-1, BxPC-3, Hs766T, MiaPaCa2, and PANC-1 cancer cells; inhibits TPA- and PdiBu-induced increases in ear thickness and epidermal hyperplasia in mice at 100 μg, topical