Product Description: Cathelicidins are a family of antimicrobial proteins predominantly found in the peroxidase-negative granules of neutrophils. During bacterial infections, the life span of neutrophils is regulated by various pathogen- and host-derived substances. The cathelicidins are synthesized as preproproteins. Within the neutrophils, they are stored in granules as inactive proforms after removal of the signal peptide. The active biologic domains of the cathelicidins generally resi
Size
0.05 mg
Concentration
n/a
Applications
Application Use: For testing of biological activity of LL-37 in vitro dilutions have to be made according to published references. It is recommended that users test the reagent and determine their own optimal concentrations.
1. Johansson J, et al; Conformation-dependent antibacterial activity of the naturally occuring human peptide LL-37. J Biol Chem 1998, 273: 3718 2. Agerberth B, et al; The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations. Blood 2000, 96: 3086 3. Yang D, et al; The role of mammalian antimicrobial peptides and proteins in awakening of innate host defences and adaptive immunity. Cell Moll Life Sci 2001, 58: 978 4. S