Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 2 μg, Western Blot: 0.1 μg/mL
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Description
Amphiphysin Monoclonal Antibody (N8-2). Amphiphysins, members of the BAR (Bin-Amphiphysin-Rvsp) protein super family, play a key role in clathrin-mediated endocytosis of synaptic vesicles (SVs). All members of the BAR family share a highly conserved N-terminal BAR domain and a C-terminal Src homology (SH3) domain. Two isoforms of amphiphysin have been identified and act in concert as a heterodimer. Amphiphysins interact via its carboxy-terminal SH3 domain with dynamin, synaptojanin and clathrin. These complexes are implicated in synaptic vesicle recycling at nerve terminal. Amphiphysins were also identified as the dominant autoantigen in paraneoplastic Stiff-Man Syndrome.
Immunogen
n/a
Other Names
AMPH; AMPH1; Stiff Man syndrome with breast cancer 128kDa autoantigen