Oncostatin M Receptor (OSMR) (AA 28-739) protein (His tag)
Description
Oncostatin-M-Specific Receptor Subunit beta (OSMRbeta) is a 150 - 180 kDa member of the IL-6 receptor family. OSMRbeta associates with gp130 to form the type II OSM receptor, the receptor is responsive to OSM. Gp130 subunit is shared by other IL-6 family cytokine receptors, and OSMRbeta associates with gp130-like receptor (GPL) to form a receptor complex responsive to IL-31. The human OSMRbeta cDNA encodes a 979 amino acid (aa) precursor, the precursor includes a 27 aa signal sequence, a 712 aa extracellular domain (ECD), a 22 aatransmembrane segment, and a 218 aa cytoplasmic domain. The ECD contains one partial and one complete hematopoietin domain, an Ig-like domain, and three Fibronectin type-III domains.Alternative Names: Oncostatin-M-Specific Receptor Subunit Beta, Interleukin-31 Receptor Subunit Beta, IL-31 Receptor Subunit Beta, IL-31R Subunit Beta, IL-31R-Beta, IL-31RB, OSMR, OSMRB