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Description
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Synonyms: Monoclonal RAD23B antibody, Anti-RAD23B antibody, RAD23 homolog B antibody, P58 antibody, HR23B antibody, HHR23B antibody.
Immunogen
RAD23 B antibody was raised in mouse using recombinant Human Rad23 Homolog B (S. Cerevisiae) (Rad23 )