Transforming Growth Factor, beta 3 (TGFB3) protein
Description
The three mammalian isoforms of TGF beta, TGF beta1, beta2, beta3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF beta isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. Alternative Names: Transforming Growth Factor-beta3 protein, TGF beta 3, TGF beta-3 protein, TGF-3b protein, TGF beta 3, TGF beta-3 protein, TGF beta-3, TGFB3 protein, TGF beta 3 protein