Granulocyte/Macrophage Colony-Stimulating Factors (M-CSF) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of granulocytes and monocytes-macrophages. M-CSF plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. It also plays an important role in innate immunity and in inflammatory processes by promoting the release of proinflammatory chemokines. M-CSF is also required for normal bone development and male/female fertility. This protein has 223 amino acids (Glu 33 - Arg 255) with a 6x-His tag at C-terminus, and a calculated MW of 26 kDa. The protein migrat