Recombinant Saccharomyces cerevisiae Probable tRNA threonylcarbamoyladenosine biosynthesis protein KAE1 (KAE1)
Description
Purity > 90% as determined by SDS-PAGE. MW: 46.7kDa. Full Length: 1-386aa. N-terminal 6xHis-tagged. Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein (s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Kinase-associated endopeptidase 1; N6-L-threonylcarbamoyladenine synthase; t (6)A synthase; t (6)A37 threonylcarbamoyladenosine biosynthesis protein KAE1; tRNA threonylcarbamoyladenosine biosynthesis protein KAE1