An insurmountable AT1 receptor antagonist (Ki = 1.3 nM); reduces blood pressure in stroke-prone spontaneously hypertensive rats and increases survival of SPSH rats fed a high-salt low-protein diet at 3, 10, and 30 mg/kg; reduces plaque formation, collagen content, as well as the increased expression of the AT1 receptor, PDGF-b, MCP-1, and VCAM-1 in a model of diabetes-induced atherosclerosis using ApoE-knockout mice with diabetes induced by STZ