An inhibitor of the release of IL-17 by CD4 T cells stimulated with IL-15, either alone or in combination with CXCL12 and anti-CD3 monoclonal antibody (IC50s = 57.4 and 25.7 nM, respectively); reduces the expression of inflammatory cytokines and inhibits joint destruction in collagen-induced arthritis in mice
Size
1 mg
Concentration
n/a
Applications
n/a
Other Names
biochemical receptor antagonist arthritis autoimmune disease cancer inhibitor immunology inflammation inhibit Y-320 IL-15 IL15 mediated CD4 T cell activation CD-4 pro-inflammatory proinflammatory cytokine rheumatoid inflammatory bowel psoriasis celiac alopecia areata IL-17 IL17 joint destruction type II 2 collagen-induced CIA mice model synergistically TNF-α TNFα ameliorating scores swelling cynomolgus monkey